Michael Niehaus has a great post over on his blog covering Office 2010 with ConfigMgr 2012 Beta 2.
The new application model in Configuration Manager 2012 will require administrators to study up on how best to deploy software – this isn’t anything like traditional software distribution like you would find in ConfigMgr 2007.
I recently set up Office 2010 as an application in ConfigMgr 2012 Beta 2. Here are the steps I used – not necessarily the only way to do it, but it worked for me.